Maternal protein restriction (MPR) can significantly affect offspring's early development and aging, impacting several organs, including the adrenal glands. This study evaluated the adrenal proteomic profile in male rat offspring exposed to MPR during pregnancy and lactation. Male offspring were divided into two groups: Control (CTR), born to dams fed a normoprotein diet (17 % protein), and Gestational and Lactational Low-Protein (GLLP), born to dams fed a low-protein diet (6 % protein) throughout gestation and lactation, and after received control diet.
View Article and Find Full Text PDFTranslation and the formation of membraneless organelles are linked mechanisms to promote cell stress surveillance. LncRNAs responsive to ethanol stress transcr_9136 of the SEY6210 strain and transcr_10027 of the BY4742 strain appear to act on tolerance to ethanol in these strains. Here, we investigate whether the ethanol responsiveness of transcr_9136 and transcr_10027 and their role in ethanol stress are associated with protein biogenesis and membraneless organelle assembly.
View Article and Find Full Text PDFThe developmental origins of health and disease (DOHaD) concept suggests that adverse conditions during gestation can influence the development and function of multiple organs, including the gastrointestinal tract. Maternal protein restriction (MPR) exposure has been associated with negative effects on reproduction, the endocrine system, and liver metabolic health. However, limited research has explored the impact of MPR on the offspring's intestinal morphophysiology.
View Article and Find Full Text PDFThis study aimed to investigate the mechanisms by which the association between maternal hyperglycemia and postnatal high-fat diet (HFD) exposure compromises metabolic parameters and hepatic autophagy in adult female pups. For this, Sprague Dawley rats, female pups from nondiabetic (control = FC) or diabetic (FD) mothers, were fed a standard diet (SD) or HFD from weaning until adulthood ( minimum = 5 rats/group): FC/SD, FC/HFD, FD/SD, and FD/HFD. In adulthood, these rats were tested with the oral glucose tolerance test, euthanized, and serum biochemistry parameters were analyzed.
View Article and Find Full Text PDFBiochem Biophys Res Commun
March 2025
We assess the effects of aerobic exercise on the soleus and plantaris muscles in adult rats submitted to maternal protein restriction (MPR) during pregnancy and lactation. Male offspring born from dams fed with control (17%-control) or low protein diets (6%-restricted) were randomly assigned to untrained or aerobic exercise, and morphological, biochemical, molecular, and proteomic analyses were performed. The proteome analysis showed many proteins involved with muscle energy metabolism, with emphasis on the glycolysis (ALDOA, ENO1, PGAM2, and TPI1) and glycogen (PYGM) pathways.
View Article and Find Full Text PDF