Publications by authors named "M Fill"
Article Synopsis
- * Researchers identified 21 human ITPR1 GOF variants and created a mouse model with one of these variants (ITPR1-W1457G), which was found to be prone to stress-induced ventricular arrhythmias.
- * Both mouse models and human data suggest that ITPR1 GOF variants increase Ca handling abnormalities and arrhythmia risk, with 7 rare ITPR1 variants in a human database showing similar GOF behavior linked to cardiac
Article Synopsis
- Holiday Heart Syndrome (HHS) is linked to excessive binge drinking, resulting in atrial fibrillation (AF), which poses significant health risks and is of great concern for prevention and treatment.
- This study explores the beneficial effects of Alda-1, which counteracts alcohol-induced calcium (Ca) abnormalities and arrhythmias in mouse atria and isolated human heart channels, suggesting a protective role in HHS-related AF.
- Findings reveal that Alda-1 inhibits JNK2 enzyme activity independently of alcohol detoxification pathways, providing insights into a potential therapeutic approach to reduce binge alcohol-related arrhythmogenic effects.
Metal-organic frameworks (MOFs) have gathered significant interest due to their tunable porosity leading to diverse potential applications. In this study, we investigate the incorporation of the fluorosolvatochromic dye 2-butyl-5,6-dimethoxyisoindoline-1,3-dione ([double bond, length as m-dash]Phth) into various MOF structures as a means to assess the polarity of these porous materials. As a purely inorganic compound, zeolite Y was tested for comparison.
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