Publications by authors named "M Fic"

Real-world processes often exhibit temporal separation between actions and reactions - a characteristic frequently ignored in many modelling frameworks. Adding temporal aspects, like time delays, introduces a higher complexity of problems and leads to models that are challenging to analyse and computationally expensive to solve. In this work, we propose an intermediate solution to resolve the issue in the framework of evolutionary game theory.

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Article Synopsis
  • The study evaluated the effectiveness of a treat-to-target (T2T) approach using faecal calprotectin (FC) levels compared to symptom-based management for mild-to-moderate ulcerative colitis (UC).
  • It was a randomized controlled trial involving 193 patients, where the interventional group utilized FC values for treatment adjustments, while the reference group relied solely on clinical symptoms.
  • Results showed no significant difference in the primary endpoint, but the T2T approach had a higher rate of achieving composite endpoint goals, indicating it may offer better disease control in the long run.
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The yeast Saccharomyces boulardii CNCM I-745 is a unique, non-bacterial microorganism classified as a probiotic agent. In this review article, at first, we briefly summarized the mechanisms responsible for its probiotic properties, e.g.

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The link between gut microbiota and the development of colorectal cancer has been investigated. An imbalance in the gut microbiota promotes the progress of colorectal carcinogenesis multiple mechanisms, including inflammation, activation of carcinogens, and tumorigenic pathways as well as damaging host DNA. Several therapeutic methods are available with which to alter the composition and the activity of gut microbiota, such as administration of prebiotics, probiotics, and synbiotics; these can confer various benefits for colorectal cancer patients.

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