Publications by authors named "M Fex"
Article Synopsis
- The study explores the genetic factors influencing β-cell function (BCF) and their relationship to type 2 diabetes (T2D), expanding on previous genetic research using large-scale data.
- By analyzing GWAS data from around 26,000 individuals, the researchers identified 55 unique genetic associations related to BCF traits derived from oral glucose tolerance tests.
- The findings reveal key genes that regulate insulin secretion and illustrate how different genetic mechanisms can affect T2D risk, offering a deeper understanding of the complex biology behind the disease.
Article Synopsis
- The study examines the effectiveness of a new automated multiplex Antibody Detection by Agglutination-PCR (ADAP) method for diagnosing type 1 diabetes compared to traditional single-plex radiobinding assays (RBA).
- It analyzed various autoantibodies in nearly 10,000 participants, aiming to establish diagnostic thresholds for identifying different stages of type 1 diabetes.
- Results showed ADAP had higher sensitivity and comparable specificity to RBA, suggesting it may be a more effective diagnostic tool for detecting multiple autoantibodies in type 1 diabetes.
Pancreatic β cells play an essential role in the control of systemic glucose homeostasis as they sense blood glucose levels and respond by secreting insulin. Upon stimulating glucose uptake in insulin-sensitive tissues post-prandially, this anabolic hormone restores blood glucose levels to pre-prandial levels. Maintaining physiological glucose levels thus relies on proper β-cell function.
View Article and Find Full Text PDFThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass.
View Article and Find Full Text PDFArticle Synopsis
- Access to Human Beta Cells
- : The study presents EndoC-βH5 cells as an advanced model for understanding human pancreatic beta cell functions and potential diabetes treatments, closely mimicking primary adult cells.
- Cell Generation and Features
- : These cells were created by integrating specific genes into human fetal pancreas, with successful removal of unwanted transgenes, resulting in cells that are easy to use and assess for insulin secretion and other functions.
- Findings and Applications
- : EndoC-βH5 cells demonstrate strong glucose-dependent insulin secretion and are suitable for drug testing and studying beta cell behavior, indicating their utility in diabetes research and therapy.