Publications by authors named "M Fernandez Rivas"
Type 1 diabetes (T1D) polygenic risk scores (PRS) are effective tools for discriminating T1D from other diabetes types and predicting T1D risk, with applications in screening and intervention trials. A previously published T1D Genetic Risk Score 2 (GRS2) is widely adopted, but challenges in standardization and accessibility have hindered broader clinical and research utility. To address this, we introduce GRS2x, a standardized and cross- compatible method for accurate T1D PRS calculation, demonstrating genotyping and reference panel independent performance across diverse datasets.
View Article and Find Full Text PDFMidline venous catheter: New insights for its use in hospitalized patients with diabetes.
Diabetes Res Clin Pract
January 2025
In a prospective study we found that in hospitalized patients with diabetes the use of mid line venous catheter (MVC) resulted in a significantly lower rate of vascular complications than short cannulas. However, a special attention should be paid to catheter obstruction when MCV is used.
View Article and Find Full Text PDFReplacement of the essential catalytic aspartate with serine leads to an active form of copper-containing nitrite reductase from the denitrifier Sinorhizobium meliloti 2011.
Biochim Biophys Acta Proteins Proteom
December 2024
Article Synopsis
- The study details the characterization of a mutated variant of copper-containing nitrite reductase (SmNirK) from S. meliloti, where the catalytic aspartate (Asp) is replaced with serine (Ser) via site-directed mutagenesis.
- The D134S variant retains the homotrimer structure and similar T1 electron transfer center to the wild-type, but shows altered electronic properties in the T2 active site, impacting its enzymatic efficiency and pH dependence.
- EPR studies reveal significant changes in the T2 properties due to the mutation, highlighting the role of T2 ligands in catalysis and suggesting a potential mechanism for electron transfer influenced by the Asp/Ser switch.