Publications by authors named "M Ferdousi"
Introduction: Painful idiopathic distal sensory polyneuropathy (IDSP) and fibromyalgia syndrome (FMS) are cryptogenic chronic pain syndromes. The contribution of small fibre pathology (SFP) in FMS remains controversial. This study aims to quantify small nerve pathology in participants with IDSP and FMS and identify relationships of SFP with sensory phenotypes.
View Article and Find Full Text PDFBackground: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder. This study aimed to study the genotype distribution of FCS-causing genes in the United Kingdom, genotype-phenotype correlation, and clinical differences between FCS and multifactorial chylomicronemia syndrome (MCS).
Methods: The study included 154 patients (FCS, 74; MCS, 80) from the UK FCS national registry and the UK arm of the FCS International Quality Improvement and Service Evaluation Project.
Article Synopsis
- - The study examined gender representation in clinical trials for FDA-approved anticancer drugs from 1998-2018, focusing on participation rates of women compared to men across various cancer types.
- - Findings indicated that women constituted only 40.7% of participants in 148 trials, with significant under-representation in trials for gastric, liver, and lung cancers, while sex-specific efficacy and safety data were rarely reported (only 4% of trials).
- - Despite low female enrollment, there was no correlation between the percentage of women recruited and drug efficacy, highlighting a persistent gap in gender representation in cancer research.
Article Synopsis
- BTK inhibitors are effective for treating B-cell malignancies but are linked to heart issues like atrial fibrillation (AF), the extent and seriousness of which were previously unknown.
- A study monitored B-cell cancer patients on BTK inhibitors from 2009-2020, revealing that 72.4% developed arrhythmias, with 16.3% experiencing new cases of AF and 14.3% showing high AF burden.
- Higher AF burden was correlated with increased risk of major cardiac events and mortality, highlighting the need for careful monitoring and management in patients treated with BTK inhibitors.
Purpose Of Review: This review endeavours to explore the aetiopathogenesis and impact of severe hypertriglyceridemia (SHTG) and chylomicronaemia on cardiovascular, and pancreatic complications and summarizes the novel pharmacological options for management.
Recent Findings: SHTG, although rare, presents significant diagnostic and therapeutic challenges. Familial chylomicronaemia syndrome (FCS), is the rare monogenic form of SHTG, associated with increased acute pancreatitis (AP) risk, whereas relatively common multifactorial chylomicronaemia syndrome (MCS) leans more towards cardiovascular complications.