Publications by authors named "M Fellhauer"
An important prerequisite for ascertaining rational antibiotic prescribing is the availability and evaluation of antibiotic use data. In this study we report evolving trends of antibiotic use in German hospitals during the last decade.Using drug dispensing data from acute care hospital pharmacies, we calculated yearly antibiotic use density values for the period from 2012/13 through to 2021/22.
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- Antimicrobial stewardship (AMS) programs improve antibiotic prescribing, necessitating regular monitoring of antibiotic use in pediatric hospitals, where the study focused on antibiotic consumption density (ACD) in 2020 across 113 German hospitals.
- The median ACD was 26.7 DDD/100 patient days, with university hospitals showing higher rates, and oncology and intensive care units having the highest densities; overall, antibiotic use declined slightly from 2013-2020, but there were notable increases in "Watch" and "Reserve" category antibiotics.
- The findings highlight significant variability in antibiotic prescribing practices and raise concerns about high cephalosporin usage and the need for AMS programs to address these issues in order to combat antimicrobial resistance.
A subgroup of patients with severe COVID-19 suffers from progression to acute respiratory distress syndrome and multiorgan failure. These patients present with progressive hyperinflammation governed by proinflammatory cytokines. An interdisciplinary COVID-19 work flow was established to detect patients with imminent or full blown hyperinflammation.
View Article and Find Full Text PDFIntroduction: In the time of increasing resistance and paucity of new drug development there is a growing need for strategies to enhance rational use of antibiotics in German and Austrian hospitals. An evidence-based guideline on recommendations for implementation of antibiotic stewardship (ABS) programmes was developed by the German Society for Infectious Diseases in association with the following societies, associations and institutions: German Society of Hospital Pharmacists, German Society for Hygiene and Microbiology, Paul Ehrlich Society for Chemotherapy, The Austrian Association of Hospital Pharmacists, Austrian Society for Infectious Diseases and Tropical Medicine, Austrian Society for Antimicrobial Chemotherapy, Robert Koch Institute.
Materials And Methods: A structured literature research was performed in the databases EMBASE, BIOSIS, MEDLINE and The Cochrane Library from January 2006 to November 2010 with an update to April 2012 (MEDLINE and The Cochrane Library).
Background: In view of increasing rates of bacterial resistance and Clostridium difficile infections efforts to enhance appropriate and intelligent antibiotic prescribing have become important. A prerequisite is the availability of reliable antibiotic use data. So far antibiotic consumption data in this country had only a very limited coverage of acute care hospitals.
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