Publications by authors named "M Farshchian"
Pancreatic ductal adenocarcinoma (PDAC) still has a poor response to therapies, partly due to their cancer-associated fibroblasts (CAFs). Here, we investigate the synergistic impact of a combinatory approach between a known chemotherapy agent, such as gemcitabine (GEM), and gene-modified human mesenchymal stromal/stem cells (MSCs) secreting the pro-apoptotic soluble (s)TRAIL (sTRAIL MSCs) on both PDAC cells and CAFs. The combo significantly impacts on PDAC survival in 2D and 3D models.
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- Acute myeloid leukemia (AML) is a prevalent type of leukemia in children, and there's a continued need for effective clinical biomarkers; this study identifies the PPP1R1B::STARD3 fusion transcript in an AML patient for the first time.
- A 12-year-old boy with symptomatic AML had chromosomal abnormalities, including t(9;22), which were confirmed through detailed analysis.
- The study suggests that the PPP1R1B::STARD3 fusion may influence cholesterol movement in cancer cells and highlights its potential as a target for therapies related to cancer metabolism and signaling pathways.
Objective: The immunoregulatory properties of mesenchymal stromal/stem cells (MSCs) bring a promise for the treatment of inflammatory diseases. However, their ability to suppress the immune system is unstable. To enhance their effectiveness against immune responses, it may be necessary to manipulate MSCs.
View Article and Find Full Text PDFSmall foreign bodies superficially embedded in the acral skin can be difficult to remove. Typical treatment includes using forceps and pressure to attempt removal, which is painful and not always successful. Here we present a patient with a prolonged presentation of a superficially embedded foreign body on his finger.
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