Publications by authors named "M Farre Pinilla"
Article Synopsis
- Congenital anemias are diverse disorders caused by abnormalities in red blood cells and can involve defects in enzymes, membranes, and hemoglobin, presenting with varying severity and symptoms.
- The study utilized Quant 3' mRNA-Sequencing to analyze gene expression in patients with sickle cell disease, thalassemia, and a rare form of congenital sideroblastic anemia (CSA), revealing distinct gene expression patterns.
- Results indicated that most congenital anemias showed upregulated genes related to metabolic processes and erythropoiesis, while the CSA patient exhibited a unique gene map, highlighting the clinical significance of these findings in understanding anemia mechanisms.
Article Synopsis
- The study investigates the CT features of Morel-Lavallée lesions (MLLs) in cats, focusing on their occurrence following trauma and their unique fluid characteristics.
- Three young cats with recurrent swelling after pelvic limb trauma were examined, all showing fluid-filled spaces between the dermis and deep fascia.
- MLLs can be easily misdiagnosed due to similar appearances to other injuries, posing risks like significant skin necrosis if not treated properly.
Background: IMPAACT 1077BF/FF (PROMISE) compared the safety/efficacy of two HIV antiretroviral therapy (ART) regimens to zidovudine (ZDV) alone during pregnancy for HIV prevention. PROMISE found an increased risk of preterm delivery (<37 weeks) with antepartum triple ART (TDF/FTC/LPV+r or ZDV/3TC/LPV+r) compared with ZDV alone. We assessed the impact of preterm birth, breastfeeding, and antepartum ART regimen on 24-month infant survival.
View Article and Find Full Text PDFMechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome.
Proc Natl Acad Sci U S A
January 2024
Nigericin, an ionophore derived from , is arguably the most commonly used tool compound to study the NLRP3 inflammasome. Recent findings, however, showed that nigericin also activates the NLRP1 inflammasome in human keratinocytes. In this study, we resolve the mechanistic basis of nigericin-driven NLRP1 inflammasome activation.
View Article and Find Full Text PDFAre both distinct epithelial and stromal cells molecular analysis from phyllodes tumors versus fibroadenoma components affected in breast fibroepithelial progression?
Acta Cir Bras
December 2023
Purpose: To determine molecular events involved in the tumorigenesis of phyllodes tumors (PT) and the role of each stromal (SC) and epithelial (EC) cell.
Methods: Frozen breast samples enriched with epithelial and stromal cells from three fibroadenomas and 14 PT were retrieved and laser microdissected. Sanger and polymerase chain reaction-based sequencing of exon 2 MED12 and TERT promoter hotspot mutations were performed; 44K microarray platform was used to analyze gene expression.