Publications by authors named "M Farnos"
Article Synopsis
- Climate change is affecting grapevine development and yield, prompting research into plant breeding to create stable grape varieties adapted to warmer climates.
- The study focused on a mapping population of 129 microvines, identifying ten stable quantitative trait loci (QTLs) related to berry development and quality, particularly a major QTL on chromosome 7 linked to berry weight and yield components.
- Results suggest that while some major genetic traits were identified in Ugni Blanc flb, minor QTLs in Picovine showed limited stability, indicating potential areas for future grapevine breeding efforts.
Article Synopsis
- Researchers aimed to find new Quantitative Trait Loci (QTLs) that influence grapevine berry weight and seed content, as only a few have been identified before.
- The study identified five new QTLs associated with berry weight and four new QTLs for seed traits, with some explaining a substantial amount of total variance (up to 51%).
- A total of nine new QTLs were discovered, significantly enhancing the potential for marker-assisted selection and candidate gene studies in grapevine cultivation.
CD6 is a transmembrane receptor expressed by all T and a subset of B lymphocytes, where it physically associates with the antigen-specific receptor to modulate activation and differentiation processes through still poorly understood mechanisms. Its cytoplasmic tail lacks intrinsic catalytic activity but presents several consensus motifs for phosphorylation. The present work reports on the identification of two constitutively phosphorylated serine clusters (S480/482/484 and S560/562/565/567/568), which are embedded into Casein Kinase 2 consensus motifs, and are indispensable for proper mitogen-activated protein kinase activation following CD6 ligation.
View Article and Find Full Text PDFThe mannose-binding lectin (MBL) pathway of complement system is activated when carbohydrate-bound MBL forms complexes with different serine proteases (MASP-1, MASP-2 and MASP-3), among which MASP-2 has a predominant functional role. Polymorphisms impairing the quantity and/or the functional activity of proteins encoded by the MBL2 and MASP2 genes have been reported in all human populations showing different allelic frequency and distribution. This likely reflects the existence of environmental influences on MBL2 and MASP2 genetic evolution.
View Article and Find Full Text PDFCD6 is a lymphocyte receptor that belongs to the scavenger receptor cysteine-rich superfamily. Because some members of the scavenger receptor cysteine-rich superfamily act as pattern recognition receptors for microbial components, we studied whether CD6 shares this function. We produced a recombinant form of the ectodomain of CD6 (rsCD6), which was indistinguishable (in apparent molecular mass, antibody reactivity, and cell binding properties) from a circulating form of CD6 affinity-purified from human serum.
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