Whole exome sequencing revealed new variants and haplotypes associated with monogenic obesity.

Objectives: This study aims to identify new variants and haplotypes associated with monogenic obesity by analyzing known obesity genes in whole exome sequencing (WES) data.

Methods: The monogenic obesity-associated genes were identified by using the National Institutes of Health (NIH) Genetic Testing Registry (GTR) monogenic obesity panels. WES was performed on ( = 49) extremely obese (children under 5 with weight-for-height greater than 3 standard deviations (SD) above the World Health Organization (WHO) Child Growth Standards median) and ( = 50) control nonobese (25 > body mass index (BMI) < 30) subjects without a history of childhood obesity, and also Iranome WES data of healthy subjects ( = 800).

Synergistic effects of doxorubicin loaded silk fibroin nanoparticles and Cu-TiO nanoparticles for local chemo-sonodynamic therapy against breast cancer.

A promising new approach to mitigate the adverse effects of chemotherapeutic drugs on healthy tissues involves combining sonodynamic therapy with topical chemotherapy to enhance the therapeutic efficacy of anticancer drugs. In this study, we introduce a multi-functional in situ chitosan hydrogel (CS) containing silk fibroin nanoparticles (SFNPs) loaded with doxorubicin (DOXSFNPs) and CuO/TiO nanoparticles (CTNPs) for combination therapy. The developed DOXSFNPs exhibited a size of 257 ± 6 nm, a zeta potential of -14.

Novel parallel inputs shift registers with terminals in nanotechnology.

This paper was focused on logic gates, D-latch, parallel-parallel shift-registers, and parallel-series shift registers, which are used as basic circuits in numerous circuits as well as computational and comparative units. To design proposed shift registers, D-latch which is the vital gate, is designed carefully for minimum size, decreasing number of cells and good performance for delay. The proposed level-sensitive parallel-in parallel-out () shift registers with reset terminal and with both set and reset terminals (single-layer and multi-layer), edge-sensitive shift registers with reset and set/reset abilities (single-layer and multi-layer), and the parallel-in serial-out () shift registers were designed using the proposed D-latches.

Genetic Variants and Haplotype Structures in the Gene Family to Predict Cancer Risk: A Bioinformatics Study.

Background And Aims: The cancer susceptibility () gene family of long noncoding RNAs (lncRNAs) plays an important role in cancer. The aim of this study was to identify genetic variants and haplotype structures of genes associated with cancer risk.

Methods: Genome-wide association studies (GWAS) significant variants ( ≤ 5 × 10) on family genes were identified from the GWAS Catalog-EMBL-EBI, and then cancer-associated variants on genes were extracted.