Publications by authors named "M Fambrini"
Selective progesterone receptor modulators for the treatment of dysmenorrhea: an update.
Expert Opin Pharmacother
January 2025
Introduction: Dysmenorrhea is a painful symptom associated with uterine contractions and menstrual bleeding and is treated by administering analgesic drugs. Since progesterone receptors (PRs) have a major role in regulating uterine tissues (myometrium and endometrium) physiology, oral contraceptives are used off-label for treating primary or secondary dysmenorrhea. The development of selective progesterone receptor modulators (SPRMs), a class of synthetic steroids with agonistic, antagonistic, or mixed effects in targeting PRs in different tissues, stimulated their possible clinical use for treating secondary dysmenorrhea related to uterine diseases (endometriosis, adenomyosis, uterine fibroids).
View Article and Find Full Text PDFObjective: To determine whether the bioactive sphingolipid sphingosine 1-phosphate (S1P) modulates cellular proliferation and synthesis of fibrotic proteins in leiomyoma differently than myometrial cells.
Design: A basic science study using human leiomyoma and myometrial cells.
Patient(s): Not applicable.
Article Synopsis
- The study aimed to evaluate whether using a V-Y reconstructive flap after surgery for vulvar cancer improves surgical outcomes compared to surgery without reconstruction.
- It involved a comparison of 361 patients, identifying risk factors for complications, with results showing that higher body mass index, diabetes, and age were linked to increased risk of wound issues.
- Findings indicated that V-Y reconstruction significantly decreased postoperative complications, especially in patients with larger lesions, highlighting its benefits for those with significant surgical defects.
The necrotrophic plant pathogenic fungus (Pers., 1794), the causative agent of gray mold disease, causes significant losses in agricultural production. Control of this fungal pathogen is quite difficult due to its wide host range and environmental persistence.
View Article and Find Full Text PDFConservative surgical treatment for adenomyosis: New options for looking beyond uterus removal.
Best Pract Res Clin Obstet Gynaecol
July 2024
Article Synopsis
- Adenomyosis is a common non-cancerous uterine disorder, often leading to symptoms like painful periods, painful intercourse, abnormal bleeding, and infertility.
- Treatment options include hormonal medications as the first line, with alternatives like radiological procedures and surgery offered if medications fail.
- While a hysterectomy is the only definitive cure, there’s a growing preference for uterus-preserving surgeries, which can effectively reduce symptoms but carry some risks, especially if endometriosis is also present.