Publications by authors named "M Falchi"
The interplay between multiple organs, known as inter-organ crosstalk, represents a complex and essential research domain in understanding the mechanisms and therapies for kidney diseases. The kidneys not only interact pathologically with many other organs but also communicate with other systems through various signaling pathways. It is of paramount importance to comprehend these mechanisms for the development of more efficient therapeutic strategies.
View Article and Find Full Text PDFStructural composite materials have gained significant appeal because of their ability to be customized for specific mechanical qualities for various applications, including avionics, wind turbines, transportation, and medical equipment. Therefore, there is a growing demand for effective and non-invasive structural health monitoring (SHM) devices to supervise the integrity of materials. This work introduces a novel sensor design, consisting of three spiral resonators optimized to operate at distinct frequencies and excited by a feeding strip line, capable of performing non-destructive structural strain monitoring via frequency coding.
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- Immunoglobulin (Ig) glycosylation significantly influences immune responses and is crucial in aging and diseases, but research has primarily focused on IgG, leaving IgA glycosylation less understood.
- Using a new liquid chromatography-mass spectrometry method, researchers created a large dataset of IgA glycosylation from 2423 twin serum samples, identifying key N- and O-glycan species.
- The findings reveal that IgA glycosylation is highly heritable, varies with sex and age, and is largely influenced by shared genetic factors, with specific genetic loci associated with IgA and IgG glycomes linked to immune disease risk, including IgA nephropathy.
Background: Vitamin A is essential for physiological processes like vision and immunity. Vitamin A's effect on gut microbiome composition, which affects absorption and metabolism of other vitamins, is still unknown. Here we examined the relationship between gut metagenome composition and six vitamin A-related metabolites (two retinoid: -retinol, 4 oxoretinoic acid (oxoRA) and four carotenoid metabolites, including beta-cryptoxanthin and three carotene diols).
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- Eosinophils, when activated by the alarmin IL-33, produce extracellular vesicles (EV) that show potential anti-tumor effects, contrasting with those activated by IL-5.
- Incorporating these IL-33-activated eosinophil-derived EV (Eo33-EV) into tumor cells leads to increased expression of genes that promote cell cycle arrest and reduces tumor growth and metastasis.
- RNA sequencing highlights that Eo33-EV are enriched with tumor suppressor genes and pathways that enhance an epithelial phenotype, indicating their potential role in cancer therapy through cell reprogramming.