[Atypical cat scratch disease: Bartonella henselae ocular and meningeal involvement].

Bartonella henselae is the etiologic agent of cat scratch disease. It typically presents as a self-limited regional lymphadenopathy and less frequently with systemic involvement and extranodal manifestations: liver, spleen, bone, eye, among others. A case of atypical cat scratch disease is presented in an immunocompetent pediatric patient, in which meningeal and ocular involvement was evidenced, the latter manifested as neuroretinitis.

Novel insights into the relationship between cerebellum and dementia: A narrative review as a toolkit for clinicians.

The role of the cerebellum in neurodegenerative disorders that target cognitive functions has been a subject of increasing interest over the past years. However, a review focused on making clinicians more aware of the role of the cerebellum in dementia is still missing. This narrative review explores the possible factors explaining the involvement of the cerebellum in different kinds of dementia by providing more insights on how this structure can be relevant in clinical practice.

Religious assessment in Italian older adults: psychometric properties of the Francis Scale of Attitude toward Christianity and the Behavioral Religiosity Scale.

Objectives: Studies have shown that religiosity (R) and spirituality (S) can positively impact older adults' life. Nevertheless, no validated tools for measuring these constructs in the older Italian population are currently available. This study investigates the psychometric properties of two of the most common measures of R and S in the literature: the Francis Scale of Attitude toward Christianity short form (FSACsf) and the Behavioral Religiosity Scale (BRS).

Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay.

Alternative splicing (AS) can regulate gene expression by introducing premature termination codons (PTCs) into spliced mRNA that subsequently elicit transcript degradation by the nonsense-mediated mRNA decay (NMD) pathway. However, the range of cellular functions controlled by this process and the factors required are poorly understood. By quantitative AS microarray profiling, we find that there are significant overlaps among the sets of PTC-introducing AS events affected by individual knockdown of the three core human NMD factors, Up-Frameshift 1 (UPF1), UPF2, and UPF3X/B.

Functional coordination of alternative splicing in the mammalian central nervous system.

Background: Alternative splicing (AS) functions to expand proteomic complexity and plays numerous important roles in gene regulation. However, the extent to which AS coordinates functions in a cell and tissue type specific manner is not known. Moreover, the sequence code that underlies cell and tissue type specific regulation of AS is poorly understood.