Maintaining peroxisome populations: a story of division and inheritance.

Eukaryotic cells divide their metabolic labor between functionally distinct, membrane-enveloped organelles, each precisely tailored for a specific set of biochemical reactions. Peroxisomes are ubiquitous, endoplasmic reticulum-derived organelles that perform requisite biochemical functions intimately connected to lipid metabolism. Upon cell division, cells have to strictly control peroxisome division and inheritance to maintain an appropriate number of peroxisomes in each cell.

Sharing the wealth: peroxisome inheritance in budding yeast.

Eukaryotic cells have evolved molecular mechanisms to ensure the faithful partitioning of cellular components during cell division. The budding yeast Saccharomyces cerevisiae has to actively deliver about half of its organelles to the growing bud, while retaining the remaining organelles in the mother cell. Until lately, little was known about the inheritance of peroxisomes.

Musculoskeletal symptoms in support staff in a large telecommunication company.

Primary Objective: The primary objective of this study was to determine the extent and severity of the musculoskeletal problems in office workers in a telecommunication company.

Research Design: A questionnaire survey was conducted to assess the prevalence of musculoskeletal disorders' symptoms, their perceived intensity and interaction with ability to work among office workers.

Methods And Procedures: The Cornell Musculoskeletal Discomfort Questionnaire and Cornell Hand Discomfort Questionnaire developed by the Human Factors and Ergonomics Laboratory at Cornell University were used on a sample of 140 office workers in a telecommunication company.

Measures of localized spinal muscle fatigue.

The objective of this study was to determine the best variable, if any, to indicate the level of localized muscle fatigue. Six male and six female subjects were studied while they exerted their maximal voluntary contraction and 40% of maximal voluntary contraction of spinal extensors in an isometric lifting activity. The electromyography (EMG) of erectores spinae at thoracic and lumbar levels was measured bilaterally.

The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae.

The faithful inheritance of organelles by daughter cells is essential to maintain the benefits afforded to eukaryotic cells by compartmentalization of biochemical functions. In Saccharomyces cerevisiae, the class V myosin, Myo2p, is involved in transporting different organelles, including the peroxisome, along actin cables to the bud. We identified Inp2p as the peroxisome-specific receptor for Myo2p.