Exploring the Role of Antibiotics in Hospice Care.

Background: The decision regarding the use of antibiotics in hospice care, whether to initiate, defer, or discontinue therapy, presents challenges. This study aims to explore the characteristics of terminally ill patients associated with antimicrobial use in hospice.

Methods: Data are from a registry study enrolling patients admitted to hospice after discharge from a hospital.

Upregulated monocyte expression of PLIN2 is associated with early arterial injury in children with overweight/obesity.

Background And Aims: Perilipin 2 (PLIN2) regulates intracellular lipid metabolism in macrophages, and thus, plays a role in atherosclerosis. Aim of the study was to evaluate whether PLIN2 dysregulation is involved in the onset of preclinical atherosclerosis in children with overweight/obesity and to explore dysregulation mechanisms.

Methods: Sixty-three children with overweight/obesity and 21 normal weight children (controls) of the same age and sex were enrolled.

Maternal Intake of n-3 Polyunsaturated Fatty Acids During Pregnancy Is Associated With Differential Methylation Profiles in Cord Blood White Cells.

A healthy diet during pregnancy is pivotal for the offspring health at birth and later in life. N-3 polyunsaturated fatty acids (n-3 PUFAs) are not endogenously produced in humans and are exclusively derived from the diet. They are pivotal for the fetus growth and neuronal development and seem beneficial in reducing the risk of cardiometabolic diseases and preventing later allergic disorders in the offspring by modulating the inflammatory immune response.

Association of Bright Liver With the PNPLA3 I148M Gene Variant in 1-Year-Old Toddlers.

Context: Nonalcoholic fatty liver disease (NAFLD) is being increasingly diagnosed at younger ages, pointing toward an early-life origin.

Objective: To evaluate the frequency and risk factors for bright liver (BL) in 1-year-old toddlers.

Design: Secondary analysis of the 1-year follow-up of the Feeding Study.

Association between Maternal and Foetal Erythrocyte Fatty Acid Profiles and Birth Weight.

Regular foetal development is crucial for assuring good health status in the offspring. The quality and quantity of maternal dietary fatty acids (FAs) can affect growth. The study aimed to: (1) investigate the association of maternal/foetal lipid profiles with birth weight (BW); and (2) compare these profiles in small, appropriate, and large for gestational age (SGA, AGA, and LGA) infants.