Publications by authors named "M Faber"
For older unfit patients receiving venetoclax-based induction, data on the significance of interim bone marrow biopies (BMBx) findings on clinical outcomes is lacking. We retrospectively evaluated interim BMBx results performed on Cycle 1 days 21-28 of venetoclax-based therapy in 69 adults with myeloid malignancies to determine whether blast clearance was associated with overall survival (OS) and overall response rate (ORR). Median age was 75 years (range 69-78).
View Article and Find Full Text PDFCardiac dysfunction and altered gene expression in acid ceramidase-deficient mice.
Am J Physiol Heart Circ Physiol
January 2025
Farber disease (FD) is an ultrarare, autosomal-recessive, lysosomal storage disorder attributed to gene mutations. FD is characterized by acid ceramidase (ACDase) deficiency and the accumulation of ceramide in various tissues. Classical FD patients typically manifest symptoms including lipogranulomatosis, respiratory complications, and neurological deficits, often leading to mortality during infancy.
View Article and Find Full Text PDFThis secondary analysis of the Eggcel-growth study investigated the effect of daily egg intake for 6 months in infants aged 6-9 months on environmental enteric dysfunction (EED) biomarkers and the association of EED markers with growth faltering. A randomised controlled trial was conducted in Jouberton, South Africa, among 500 infants randomly assigned equally to either an intervention group receiving a daily chicken egg or a control group. Both groups were followed up for 6 months.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on infants aged 6 to 9 months in a low-income area of South Africa, exploring the effects of daily egg consumption over 6 months as a part of a larger trial.
- Infants who received eggs had a higher incidence of gastrointestinal issues (17.0% vs. 11.9%) compared to the control group, with those issues also lasting longer (1.5 days more).
- The findings suggest that while egg consumption may be beneficial for growth, it could also raise the risk of gastrointestinal morbidity in these infants.
Objective: To conduct a systematic review of the published peer-reviewed articles on the biochemical assessment of nutritional status of South African infants, children and adolescents in 1997-2022.
Design: Online databases (Pubmed, CINAHL, EbscoHost and SAePublications) were used to identify thirty-nine papers.
Setting: South Africa, 1997-2022.