Publications by authors named "M F Yueh"
Article Synopsis
- The research introduces a novel method that uses optimal mass transportation (OMT) to convert irregular 3D brain images into a cube format suited for U-net algorithms in medical imaging.
- A cubic volume-measure-preserving OMT (V-OMT) model is developed alongside a two-phase residual U-net algorithm to accurately predict and refine the tumor regions in the brain images.
- The method was validated using a dataset from the Brain Tumor Segmentation (BraTS) 2021, showing notable improvements in the accuracy of brain tumor detection and segmentation, with high Dice scores reported for different tumor regions.
Optimal mass transport (OMT) theory, the goal of which is to move any irregular 3D object (i.e., the brain) without causing significant distortion, is used to preprocess brain tumor datasets for the first time in this paper.
View Article and Find Full Text PDFTriclosan (TCS), employed as an antiseptic and disinfectant, comes into direct contact with humans through a plethora of consumer products and its rising environmental release. We have demonstrated that TCS promotes liver tumorigenesis in mice, yet the biological and molecular mechanisms by which TCS exerts its toxicity, especially in early stages of liver disease, are largely unexplored. When mice were fed a high-fat diet (HFD), we found that fatty liver and dyslipidemia are prominent early signs of liver abnormality induced by TCS.
View Article and Find Full Text PDFArticle Synopsis
- - The gastrointestinal tract contains proteins crucial for processing various substances, and genetically modified mouse models help scientists understand how these proteins affect drug metabolism.
- - Researchers used three-dimensional organoid cultures derived from these mice to study how drugs are metabolized and their potential toxicity in the intestines.
- - Their experiments showed that specific treatments affected gene expression related to drug metabolism, and organoid cultures were identified as a valuable tool for in vitro investigations of intestinal drug metabolism and related toxic effects.