[Immunogenetic analysis of pathomorphological forms and prognosis of chronic glomerulonephritis].

Aim: To ascertain whether HLA antigens are associated with morphological forms of chronic glomerulonephritis (CGN).

Material And Methods: A retrospective analysis was made of HLA distribution in 122 patients with proliferative and nonproliferative forms of CGN at different stages of fibroplastic transformation and addition of the tubulointerstitial component. Testing of HLA antigens of class I was conducted by lymphocytotoxicity; specificity of DRBI genes was investigated by DNA polymerase chain reaction.

[Immunogenetic analysis of variants of a clinical course and prognosis of chronic glomerulonephritis in the west Siberia].

Aim: To analyze association of HLA antigens with clinical variants of chronic glomerulonephritis (CGN)in 106 patients.

Material And Methods: HLA association with the time of development of terminal chronic renal failure (CRF) from the moment of detection of initial CRF was studied in 80 patients. Determination of HLA of class I was conducted in the lymphocytotoxic test.

[Evolutionary trends in symptoms of acute glomerulonephritis in adult population of the Novosibirsk region].

Acute glomerulonephritis (AGN) trends in the last 3 decades in the Novosibirsk Region have been analysed basing on the data from 308 AGN case histories. The results of the analysis demonstrate that AGN occurs not often but with stable rate. It is encountered more frequently in young men.

[Prognostic criteria for the clinical course of systemic lupus erythematosus].

To develop some individual prognostic criteria of SLE clinical course the Wald's analysis of immunogenetic markers (HLA) was used. The obtained summarized diagnostic coefficients allow predicting a subacute or chronic pattern of the disease, the rate of generalization and the most frequent location of the process in certain organs. The constant character of HLA-typing results and the simplicity of the given prognostic tables made the proposed diagnostic method convenient for medical practice.

[Investigation of tofizopam impurities using high performance liquid chromatography].

The identification and quantification of potential impurities of Tofisopam have been studied by high performance liquid chromatography. The best separation was obtained in a reversed phase system using a C18 stationary phase and 46:31:23 mixture of 0.01 M aqueous 1-hepatanesulphonic acid-sodium-acetonitrile-methanol as the mobile phase.