Efficacy and safety of colchicine for the treatment of myopericarditis.

Objective: Clinical trials have evaluated the efficacy and safety of colchicine only in simple pericarditis, excluding cases of concomitant myocarditis. The aim of this paper is to evaluate the efficacy and safety of colchicine for the treatment of the first attack of acute pericarditis with concomitant myocardial involvement.

Methods: Double-centre retrospective cohort study analysing consecutive patients admitted for first attack of pericarditis with myocarditis and treated with or without colchicine.

Attentional adjustment in priming tasks: control strategies depend on context.

Goal-directed behavior is assumed to require processes of attentional biasing to counter unwanted action tendencies elicited by distracting stimulus information. This is particularly so if stimulus categories that define the target and the distractor frequently reverse, requiring participants to respond to previously ignored stimulus categories and vice versa. In the current study, we investigated control strategies under such conditions.

Dissociating selectivity adjustments from temporal learning-introducing the context-dependent proportion congruency effect.

The list-level proportion congruency effect (PCE) and the context-specific PC (CSPC) effect are typical findings in experimental conflict protocols, which competing explanations attribute to different mechanisms. Of these mechanisms, stimulus-unspecific conflict-induced selectivity adjustments have attracted the most interest, from various disciplines. Recent methodological advances have yielded an experimental procedure for entirely ruling out all stimulus-specific alternatives.

Synthesis of Highly Congested Tertiary Alcohols via the [3,3] Radical Deconstruction of Breslow Intermediates.

Pericyclic processes such as [3,3]-sigmatropic rearrangements leading to the rapid generation of molecular complexity constitute highly valuable tools in organic synthesis. Herein, we report the formation of particularly hindered tertiary alcohols via rearrangement of Breslow intermediates formed in situ from readily available -allyl thiazolium salts and benzaldehyde derivatives. Experimental mechanistic studies performed suggest that the reaction proceeds via a close radical pair which recombine in a regio- and diastereoselective manner, formally leading to [3,3]-rearranged products.

Adjustments of selective attention to response conflict - controlling for perceptual conflict, target-distractor identity, and congruency level sequence pertaining to the congruency sequence effect.

The congruency sequence effect (CSE) describes the performance difference of congruent trials (in which target and distractor stimuli are associated with the same response) compared to incongruent trials (in which target and distractor stimuli are associated with different responses) as a function of the preceding congruency level (congruent trials relative to incongruent trials). The CSE is commonly interpreted as a measure of conflict-induced attentional adjustment. Although previous research has made substantial progress aiming at controlling for alternative explanations of the CSE, both task-specific and fundamental confounds have remained.