Publications by authors named "M F Savard"
Article Synopsis
- Intra-annual variations of carbon stable isotope ratios (δ13C) in tree compartments can indicate plant carbon source-sink dynamics on a weekly basis, but tracking these variations has been challenging due to the complexity of tree ring development.
- A new method was developed to monitor weekly δ13C variability in the cambium-xylem continuum of black spruce trees over multiple growing seasons in Quebec, allowing researchers to create δ13C series for both growing cambium and developing xylem cellulose.
- Strong positive correlations between δ13C values suggest a consistent supply of fresh carbon to support tree growth, while trends in δ13C indicate potential shifts in carbon allocation strategies related to environmental factors such as seasonal light changes.
Concerns exist regarding increased toxicities, including endocrine therapy toxicity, with concurrent radiation and endocrine therapy in early breast cancer (EBC). We present a pragmatic, randomized trial comparing concurrent versus sequential endocrine and radiotherapy in hormone-responsive EBC. In this multicenter trial, patients were randomized to receive adjuvant endocrine therapy concurrent with, or sequential to, radiotherapy.
View Article and Find Full Text PDFPurpose: While adjuvant bisphosphonate use in early breast cancer (EBC) is associated with improvements in breast cancer-specific outcomes, questions remain around optimal bisphosphonate type, dose and scheduling. We evaluated a single zoledronate infusion in a prospective randomised trial.
Methods: Postmenopausal patients with EBC were randomised to receive a single infusion of zoledronate (4 mg IV) or 6-monthly treatment for 3 years.
Most patients diagnosed with and dying from cancer in Canada are older adults, with aging contributing to the large projected growth in cancer incidence. Older adults with cancer have unique needs, and on a global scale increasing efforts have been made to address recognized gaps in their cancer care. However, in Canada, geriatric oncology remains a new and developing field.
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