Hybrid bagging and boosting with SHAP based feature selection for enhanced predictive modeling in intrusion detection systems.

The novelty and growing sophistication of cyber threats mean that high accuracy and interpretable machine learning models are needed more than ever before for Intrusion Detection and Prevention Systems. This study aims to solve this challenge by applying Explainable AI techniques, including Shapley Additive explanations feature selection, to improve model performance, robustness, and transparency. The method systematically employs different classifiers and proposes a new hybrid method called Hybrid Bagging-Boosting and Boosting on Residuals.

Assessing Human Lung Pharmacokinetics Using Exhaled Breath Particles.

It remains challenging to quantify lung pharmacokinetics (PK) of a drug administered and targeted to act in the lung. Exhaled breath particles (PEx), which are generated when collapsed distal airways reopen during inhalation, offer a noninvasive way to access undiluted epithelial lining fluid (ELF). Therefore, it was the aim of this study to investigate whether PK data can be derived from PEx.

Unlocking the Therapeutic and Antimicrobial Potential of L. Seed Kernel Oil.

The L. (bitter apricot) is an apricot fruit tree categorized on the basis of the bitter taste of its seed kernel. In this study, the functional, medicinal, and therapeutic potential of bitter apricot seed kernel oil (BASKO) was evaluated.

Efficacy and safety of tozorakimab in moderate-to-severe atopic dermatitis: A Phase 2a randomized controlled trial (FRONTIER-2).

Background: Atopic dermatitis (AD) is a chronic, inflammatory skin disease characterized by intense pruritus and eczematous lesions. Tozorakimab is a high-affinity human monoclonal antibody that neutralizes interleukin-33, a broad-acting alarmin cytokine that is over-expressed in keratinocytes of patients with AD.

Objectives: This Phase 2a study (FRONTIER-2; NCT04212169) evaluated the safety and efficacy of tozorakimab in adults with moderate-to-severe AD.

Treatment modalities for claw horn lesions and their effects on locomotion scores, gait properties, lesion progression, and nociceptive threshold in dairy cows: A systematic review.

This systematic review presents scientific evidence on treatment modalities for claw horn lesions (CHLs) in dairy cows, and their efficacy in restoring normal gait, resolution of claw lesions, and improving nociceptive threshold. A literature search was performed in four databases leading to the synthesis of 10 articles for the final analysis. The types of treatment administered include single (STM), bimodal (BTM) and multimodal treatment modalities (MTM).