Publications by authors named "M F Reschke"
Article Synopsis
- Epidural opioids, such as methadone and morphine, are used for managing acute postoperative pain, but this study investigates whether methadone provides better localized pain relief (segmental analgesia) than morphine.
- In the study, 13 healthy volunteers received epidural injections of either 4 mg of methadone or morphine and their pain tolerance was tested across different body regions for 24 hours.
- Results showed no significant difference in localized pain relief between the two drugs, although morphine resulted in longer-lasting analgesia and more systemic side effects compared to methadone, which had a better side effect profile.
Article Synopsis
- * A study was conducted via an online survey among specialists in Germany, Austria, and Switzerland to assess current practices in diagnosing and managing MTS in children and young adults, with responses from 33 professionals, predominantly from pediatric hospitals.
- * The findings revealed significant variations in diagnostic methods and treatment approaches, with many specialists using venous ultrasound and managing MTS through anticoagulation or stent placement, indicating a need for standardized guidelines to improve care and patient outcomes
Objective: The objective of this paper is to document the feasibility of image acquisition, image optimization, and sonographic appearance of the exposed anatomic windows of cadaveric inner ear dissection for purposes of potential future clinical evaluation as part of the developing area of physical and rehabilitation space medicine.
Methods: Cadaveric dissection of the inner ear was conducted with the goal of exposing areas relevant to vestibular balance. Middle and inner ear structures of 3 human cadavers were imaged with multiple broadband transducers, including emphasis with higher frequency transducers.
The Werner syndrome RecQ helicase WRN was identified as a synthetic lethal target in cancer cells with microsatellite instability (MSI) by several genetic screens. Despite advances in treatment with immune checkpoint inhibitors, there is an unmet need in the treatment of MSI cancers. Here we report the structural, biochemical, cellular and pharmacological characterization of the clinical-stage WRN helicase inhibitor HRO761, which was identified through an innovative hit-finding and lead-optimization strategy.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to assess how well the platelet function analyzer (PFA) and the ISTH bleeding assessment tool (ISTH-BAT) can detect mild inherited platelet function disorders (IPFDs) in children suspected of having bleeding issues.
- - Researchers evaluated 97 patients, identifying 34 with von Willebrand disease (VWD), 29 with various IPFDs, and 34 with no diagnosis; the diagnostic performance for detecting IPFDs was low overall, with the combination of PFA and ISTH-BAT showing a weaker correlation than expected.
- - The findings concluded that neither ISTH-BAT nor PFA effectively diagnose mild IPFDs in children, although PFA was better at ruling out severe cases,