Mutations in 406 Are Associated with Low-Level Ethambutol Resistance in Canadian Isolates.

In , molecular predictions of ethambutol resistance rely primarily on the detection of mutations within . However, discordance between 406 mutations and gold standard phenotypic drug sensitivity testing (DST) questions the significance of 406 mutations used in molecular DST. This study tabulates mutations found in Canadian isolates and evaluates the impact of specific mutations on ethambutol resistance.

Evaluation of Whole Genome Sequencing-Based Predictions of Antimicrobial Resistance to TB First Line Agents: A Lesson from 5 Years of Data.

Phenotypic susceptibility testing of the complex (MTBC) isolate requires culture growth, which can delay rapid detection of resistant cases. Whole genome sequencing (WGS) and data analysis pipelines can assist in predicting resistance to antimicrobials used in the treatment of tuberculosis (TB). This study compared phenotypic susceptibility testing results and WGS-based predictions of antimicrobial resistance (AMR) to four first-line antimicrobials-isoniazid, rifampin, ethambutol, and pyrazinamide-for MTBC isolates tested between the years 2018-2022.

Transforming medical education in Liberia through an international community of inquiry.

A critical component of building capacity in Liberia's physician workforce involves strengthening the country's only medical school, A.M. Dogliotti School of Medicine.

Underutilization and disparities in access to EGFR testing among Medicare patients with lung cancer from 2010 - 2013.

Background: Tumor testing for mutations in the epidermal growth factor receptor (EGFR) gene is indicated for all newly diagnosed, metastatic lung cancer patients, who may be candidates for first-line treatment with an EGFR tyrosine kinase inhibitor. Few studies have analyzed population-level testing.

Methods: We identified clinical, demographic, and regional predictors of EGFR & KRAS testing among Medicare beneficiaries with a new diagnosis of lung cancer in 2011-2013 claims.

Hemorrhagic unilateral retinopathy.

Purpose: To evaluate the possible etiologies of a hemorrhagic unilateral retinopathy in healthy patients.

Methods: Retrospective case series and review of the literature. All patients underwent a detailed ophthalmologic evaluation and analyses of their medical histories.