Publications by authors named "M F Pinette"

The umbilical cord is the connection between mother and fetus through which gases and nutrients are exchanged. It's remarkable structure allows for freedom of movement while providing a cushioned, protected conduit from mother to fetus. Fetal development and survival are dependent upon the umbilical cord.

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Two cat nasal swabs from Canada's earliest confirmed SARS-CoV-2 positive domestic cats were sequenced to over 99% SARS-CoV-2 genome coverage. One cat had lineage A.23.

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Crimean-Congo haemorrhagic fever orthonairovirus (CCHFV) is a tick-borne, risk group 4 pathogen that often causes a severe haemorrhagic disease in humans (CCHF) with high case fatality rates. The virus is believed to be maintained in a tick-vertebrate-tick ecological cycle involving numerous wild and domestic animal species; however the biology of CCHFV infection in these animals remains poorly understood. Here, we experimentally infect domestic sheep with CCHFV Kosovo Hoti, a clinical isolate representing high pathogenicity to humans and increasingly utilized in current research.

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Domestic pigs are a critical component of the food supply and one of the most commonly raised production animals. Pork consumption has driven the intensification of pig production expanding into environments conducive to increased emergence and spread of infectious diseases, including the spillover of pathogens into human populations. One of these emerging viruses, Reston virus (RESTV), is an enigma among the Orthoebolavirus genus in that its lack of human pathogenicity is in stark contrast to the high virulence associated with most other ebolaviruses.

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Article Synopsis
  • The study aimed to create an animal model that distinguishes between joint instability and inflammation's effects on posttraumatic osteoarthritis (PTOA), proposing that their modified drilling procedure would induce cartilage damage and inflammation without altering gait.
  • Twenty-four Yucatan minipigs were divided into two groups, one undergoing the modified intra-articular drilling (mIAD) and the other serving as a sham control, with outcomes assessed through various evaluations 15 weeks post-surgery.
  • Results showed that mIAD knees had significantly more cartilage damage and inflammation markers than controls, but no notable changes in gait mechanics, suggesting this model is useful for studying inflammatory roles in PTOA and developing relevant therapies.
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