Publications by authors named "M F O'Hare"
Messenger RNA (mRNA)-based therapies are a promising approach to medical treatment. Except for infectious diseases, no other disease has mRNA-based therapies available. The eye is an ideal model for mRNA therapeutic development because it requires limited dosing.
View Article and Find Full Text PDFIntroduction: Common mental disorders, such as anxiety disorders, depression, and posttraumatic stress disorder (PTSD), present a substantial health and economic burden. The gut microbiome has been associated with these psychiatric disorders via the microbiome-gut-brain axis. However, previous studies have focused on the associations between the gut microbiome and common mental disorders in European, North American, and Asian populations.
View Article and Find Full Text PDFArticle Synopsis
- The world is nearing the critical threshold of 1.5°C warming, with 2023 recording an average temperature rise of 1.45°C since pre-industrial times, leading to severe climate-related impacts.
- The Countdown collaboration, formed to assess the health impacts of climate change post-Paris Agreement, involves over 300 experts analyzing data and trends annually.
- The 2024 report highlights troubling increases in climate-related health risks, such as a staggering 167% rise in heat-related deaths among seniors, indicating worsening conditions affecting wellbeing globally.
Population pharmacokinetics/pharmacodynamics of minocycline plus rifampicin in patients with complicated skin and skin structure infections caused by MRSA.
Sonia Luque Pardos William Hope Antigone Kotsaki Shampa Das Evangelos J Giamarellos-Bourboulis Miriam O'Hare
J Antimicrob Chemother
December 2024
Article Synopsis
- - The study aimed to analyze how the antibiotics minocycline, rifampicin, and linezolid perform in treating infections caused by MRSA in a population setting, using pharmacokinetics and pharmacodynamics data.
- - Researchers collected samples during a Phase 4 trial, comparing the effectiveness of oral minocycline plus rifampicin against linezolid, finding minocycline plus rifampicin to be just as effective as linezolid.
- - Despite most patients meeting the drug concentration targets for effective treatment, the study concluded that the pharmacokinetic/pharmacodynamic measurements did not correlate with clinical outcomes, meaning the expected model did not predict how well patients would respond to the treatment.