Evaluation of hematological markers as prognostic tools in rheumatoid arthritis.

Background: Reducing inflammation is central to the management of RA. However, commonly used markers such as CRP and ESR, along with the DAS-28 score, have shown limitations. Hematologic indices, such as platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and neutrophil-lymphocyte ratio (NLR), show potential as reliable indicators of inflammation in RA.

Quantitative real-time PCR analysis of gut microbiota in rheumatoid arthritis patients compared to healthy controls.

Rheumatoid arthritis (RA) is an autoimmune disorder with synovial inflammation of joints and extra articular manifestations. The results of recent researches consider the relationship between microbiota and the immune system as a double-edged sword. Considering that the relationship between the composition of intestinal microbiota and the immunological and clinical status of the body has been confirmed, it is very important to investigate the effect of each genus and species of bacteria on the state of the immune system.

The Presence of Food Addiction in Patients with Binge Eating Disorder Was Associated with Higher Weight, Poor Body Composition Outcomes, Lower Serum Level of Magnesium and Higher Ferritin 2 Years Post-LSG Surgery.

Background: This study examined the presence of food addiction (FA) in patients with binge eating disorder (BED) 2 years after laparoscopic sleeve gastrectomy (LSG) and explored its association with some minerals, ferritin, weight loss and, body composition outcomes.

Materials And Methods: In this study, 120 patients with BED who had undergone LSG 2 years prior to participation were enrolled. BED was assessed using Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria and presence of FA was assessed using the Yale Food Addiction Scale (YFAS).

Incidence and survival of rare adult solid cancers in Europe (EUROCARE-6): A population-based study.

Background: Rare cancers correspond to approximately 200 clinical entities, which can be grouped into 12 families. Updated data are available for childhood and haematological cancers, ie, for only two of the 12 families of rare cancer. We provide incidence and survival for the remaining ten families of rare adult solid cancers (RAC), across 29 EU Member States and over time.

Isochroman-3,4-dione and Tandem Aerobic Oxidation of 4-Bromoisochroman-3-one in the Highly Regio- and Diastereoselective Diels-Alder Reaction for the Construction of Bridged Polycyclic Lactones.

Herein we report two processes facilitated by diisopropylethylamine (DIPEA) for the synthesis of novel bridged polycyclic molecule analogues to natural products. The use of 4-bromoisochroman-3-one initiated an autoxidation reaction, followed by a Diels-Alder cycloaddition in the presence of electron-deficient dienophiles. Mechanistic studies revealed isochromane-3,4-dione as a key intermediate, which undergoes in situ dienolization/dearomatization followed by a [4 + 2] cycloaddition.