Publications by authors named "M F Marsh"
Article Synopsis
- Chronic sleep deprivation increases the risk of Alzheimer's and dementia by impairing cerebrovascular reactivity and neurovascular coupling.
- This study focused on how a single night of restricted sleep affects cerebral blood flow (CBF) when under stress from carbon dioxide and cognitive tasks.
- Results showed that while resting CBF wasn’t impacted, the brain's response to cognitive challenges was significantly reduced after sleep restriction, highlighting the critical role of sleep in maintaining healthy brain function.
Acute lung Injury leads to alterations in surfactant lipid composition and metabolism. Although several mechanisms contribute to dysregulated surfactant metabolism, studies investigating in vivo surfactant metabolism are limited. The aim of this study is to characterise surfactant phospholipid composition and flux utilising a stable isotope labelling technique in mechanically ventilated paediatric patients.
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- A recent study investigated outcomes for children with cochlear implants affected by a Field Corrective Action (FCA), focusing on device failure rates and speech improvement after revisions.
- The study included 27 pediatric patients from March 2017 to January 2020, finding that 73% of the implants failed, with a majority undergoing revision surgery.
- Despite the high failure rate, speech recognition scores after revision surgery did not show significant improvement compared to before, indicating that the speech outcomes remained stable, potentially due to thorough monitoring and support from a specialized team.*
Background: Patient navigation interventions (PNIs) can provide personalized support and promote appropriate coordination or continuation of health and social care services. Online PNIs have demonstrated excellent potential for improving patient knowledge, transition readiness, self-efficacy, and use of services. However, the characteristics (ie, intervention type, mode of delivery, duration, frequency, outcomes and outcome measures, underlying theories or mechanisms of change of the intervention, and impact) of existing online PNIs to support the health and social needs of individuals with illness remain unclear.
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- The approval of induced pluripotent stem cells (iPSCs) for cell therapies is moving forward after two decades of research and development, with a focus on clinical trials.
- A new Working Group by the International Society for Cell and Gene Therapy is guiding users on how to create stable and well-characterized iPSCs for various therapies.
- Important factors to consider include intellectual property, raw material selection, regulatory guidelines, culture methods, and the technologies needed for processing and storing iPSCs, alongside suggestions for improving existing procedures.