Impact of the COVID-19 pandemic on tobacco product consumption and behavioral patterns from a low-middle income country perspective: A qualitative study.

Introduction: Previous studies investigating socioeconomic status and tobacco consumption during the COVID-19 pandemic were survey-based. To extend knowledge beyond prevalence rates and trends of tobacco consumption, qualitative research is needed to identify individual's experiences. There is a critical gap within this context, particularly in low-middle income countries.

Toward European harmonization of national myasthenia gravis registries: modified Delphi procedure-based expert consensus on collectable data.

Background: Myasthenia gravis (MG) is a rare autoimmune disorder. Several new treatment concepts have emerged in recent years, but access to these treatments varies due to differing national reimbursement regulations, leading to disparities across Europe. This highlights the need for high-quality data collection by stakeholders to establish MG registries.

The role of N-glycans in regulatory T cells in autoimmunity.

Regulatory T cells (Tregs) have a key role in the maintenance of immune tolerance and in the prevention of autoimmunity. Recent studies have shown an association between decreased Treg frequency and a deficient suppressive activity with the development of many autoimmune diseases. Although glycosylation, which consists in the addition of glycans to proteins and lipids on the cell surface, is recognized as a critical modification for T cell development and function, the relevance of glycans in Treg biology and activity, as well as their impact in the immunopathogenesis of autoimmune diseases, deserves more attention, as it is far from being fully understood.

Correction: Yield of soybean genotypes identified through GGE biplot and path analysis.

[This corrects the article DOI: 10.1371/journal.pone.

Positional mitral regurgitation: a dynamic phenomenon.

Mitral regurgitation (MR) is a dynamic condition influenced by positional changes and physical stress. We report a case of severe positional MR in a 74-year-old woman with dilated cardiomyopathy, highlighted by echocardiographic findings of leaflet tethering and restricted mobility. Upright positioning significantly alleviated symptoms and MR severity, underscoring the impact of hemodynamic factors on its clinical presentation.