Publications by authors named "M F Le Potier"
Down syndrome (DS) or trisomy 21 (T21) is present in a significant number of children and adults around the world and is associated with cognitive and medical challenges. Through research, the T21 Research Society (T21RS), established in 2014, unites a worldwide community dedicated to understanding the impact of T21 on biological systems and improving the quality of life of people with DS across the lifespan. T21RS hosts an international conference every two years to support collaboration, dissemination, and information sharing for this goal.
View Article and Find Full Text PDFSchizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal.
View Article and Find Full Text PDFArticle Synopsis
- Alzheimer’s disease (AD) features include amyloid plaques and tau tangles, with differences in amyloid deposition noted in patients with APP duplications (APPdup) and Down syndrome (DS).
- The study highlights that while AD typically has extensive Aβ deposits in the brain, APPdup and DS-AD show more Aβ in blood vessels, particularly with shorter Aβ peptides.
- Significant differences were found in the types and locations of Aβ deposits among APPdup, DS-AD, sporadic AD cases, and controls, indicating distinct pathology linked to additional copies of the APP gene.
Comparative evaluation of disease dynamics in wild boar and domestic pigs experimentally inoculated intranasally with the European highly virulent African swine fever virus genotype II strain "Armenia 2007".
Vet Res
July 2024
Article Synopsis
- African swine fever virus (ASFV) has spread in Europe and Asia, and wild boar help spread this virus.
- Researchers studied how domestic pigs and wild boar get infected with ASFV by comparing their reactions and health over several days after infection.
- Wild boar got sick from the virus faster than domestic pigs and showed some differences in symptoms, but overall, both had limited virus spread in their noses and bottoms during early infections.