Publications by authors named "M F L Derks"
Basilicata and Apulian (BAS-APU) turkeys, a native population in the Basilicata and Puglia regions of southern Italy, are known for their high meat quality and tolerance to local conditions. Understanding the genomic patterns of BAS-APU turkeys is critical for effective breeding and preservation strategies. In this study, we characterized runs of homozygosity (ROH), and selection signatures using the integrated haplotype score (iHS) and ROH approaches.
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- This research presents a comprehensive pangenome assembly of 27 pig genomes, marking a major milestone in pig genomic data.
- The analysis highlights how structural variations influence adaptation and breed-specific traits, identifying a crucial gene linked to intramuscular fat and meat quality.
- These findings emphasize the importance of multi-genome studies in discovering significant genomic traits for agricultural improvement.
Article Synopsis
- Italian local turkey populations are crucial for maintaining genetic diversity, and efforts should focus on in vivo preservation methods.
- Advanced genomic techniques, including whole genome sequencing and genotyping, revealed significant genetic variability and isolation among different turkey populations in Italy.
- Findings highlight the role of selective sweeps in shaping genetic traits related to heat stress and growth, suggesting potential benefits in adapting to climate change, which can inform conservation and selection strategies for these turkeys.
Efficacy and safety of balovaptan for posttraumatic stress disorder: A randomized, placebo-controlled trial.
Exp Clin Psychopharmacol
February 2025
Article Synopsis
- PTSD affects over 13 million people in the U.S. and has limited treatment options, leading to a study of balovaptan, a vasopressin 1a receptor antagonist, to evaluate its effectiveness.
- In a Phase 2 trial, 57 adults were screened, and 29 were randomly assigned to either balovaptan or a placebo, with no significant differences in PTSD symptom severity observed after 12 weeks.
- Both treatment groups tolerated the medication well, but adverse events were reported more frequently in the balovaptan group than in the placebo group.