Publications by authors named "M F Juruena"
Background: Ketamine has demonstrated both rapid and sustained efficacy in treating depression, especially in treatment-resistant cases. However, concerns regarding the addictive potential of ketamine during long-term depression treatment persist among clinicians.
Aim: This review aimed to summarise the evidence on addiction phenomena associated with ketamine treatment of depression.
Exploring the impact of childhood maltreatment on epigenetic and brain-derived neurotrophic factor changes in bipolar disorder and healthy control.
Eur Arch Psychiatry Clin Neurosci
November 2024
Article Synopsis
- Childhood maltreatment is linked to changes in epigenetics and brain-derived neurotrophic factor (BDNF), which play a role in psychiatric conditions like bipolar disorder (BD), though specific mechanisms are still unclear.
- The study involved 36 BD patients and 46 healthy controls, using the Childhood Trauma Questionnaire (CTQ) to evaluate the history of maltreatment and various biological markers related to epigenetics and BDNF.
- Findings indicate that emotional abuse is the main type of childhood maltreatment affecting epigenetic markers in BD, but it is suggested that these effects are cumulative and may interact with other factors influencing BD, rather than being a direct cause of the disorder.
Treatment for Depression in Patients Who Have Suffered from Early Life Stress.
Psychiatr Danub
September 2024
Background: People with Major Depressive Disorder (MDD) are far more likely to suffer from Early Life Stress (ELS) than the average population. This typically increases severity of symptoms, and often leads to treatment resistance. This study set out to examine which treatments work best to treat depression in patients who have suffered from ELS, as well as possible interactions between ELS and antidepressant effects in therapies.
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