Sensorineural and peripheral vascular responses induced by exposure to high-frequency vibration.

Background: Dentists, dental hygienist, and veterinary technicians using drills, scalers and polishers are at risk of developing sensorineural deficits in the fingers and hands. The goal of this study was to determine whether exposure to high-frequency vibration contributed to changes in sensory function.

Methods: The tails of rats were exposed to vibration at 1250 Hz (constant acceleration of 49 m/s2) for 4 hours per day, for 10 days.

Post-polio hospital admissions in Australia over a 10-year period: An observational study and analysis of trends by month, location, and comparable conditions.

Background: There is currently no precise estimate of post-polio conditions in Australia. This observational study aimed to provide a summary of hospitalisations over a 10-year period in Australia, with a specific focus on annual, monthly, and regional trends, as well as a comparison with four similar neurological conditions.

Methods: A retrospective cohort study of late effects of polio and post-polio syndrome from 2011 to 2021.

The interplay between endothelial glycocalyx maturity and both the toxicity and intracellular uptake of charged nanoparticles.

Nanoparticles are widely studied for delivering treatments to target tissues, but few have reached clinical use. Most nanoparticles encounter blood vessels on their way to target tissues. The inner surface of these vessels is lined with endothelial cells covered by a glycocalyx, an extracellular matrix rich in anionic glycans.

The DosR regulon of and adaptation to hypoxia.

Like other tuberculous and nontuberculous mycobacterial pathogens of human lung such as and , is likely exposed to a variety of stressors during infection, including hypoxic conditions inside activated macrophages and in the avascular necrotic regions of granulomas. How survives hypoxic stress to establish a chronic infection is currently not well understood. Using RNA-sequencing, we here show that grown under progressive microaerophilic conditions activates more than 4-fold a subset of 16 genes, the expression of 13 of which is dependent on the two-component system regulator DosRS.

Multiple Stressors Simplify Freshwater Food Webs.

Globally, freshwater ecosystems are threatened by multiple stressors, yet our knowledge of how they interact to affect food web structure remains scant. To address this knowledge gap, we conducted a large-scale mesocosm experiment to quantify the single and combined effects of three common anthropogenic stressors: warming, increased nutrient loading, and insecticide pollution, on the network structure of shallow lake food webs. We identified both antagonistic and synergistic interactive effects depending on whether the stressors affected negative or positive feedback loops, respectively.