[Possibility of enzymatic lactate disintegration followed by formate production].

A possibility of lactate reverse desintegration to formate and acetaldehyde by lactate-synthase was established by the methods of enzymatic analysis, isotope indication, thin layer chromatography.

[Role of formic acid in transformation of acetic and succinic acids in animal tissues].

Acetic and succinate acids KoA acyl derivatives interacting with formate were displayed to produce alpha-ketoacids--pyruvate and alpha-ketoglutarate. These acids also interact with formate and make pyruvic and malate acids, while alpha-ketoglutarate, evidently, tricarboxy acids. Interaction of formate with acetic and succinate acids inspite of occurring out of the tricarbone cycle increases the latter metabolic functions.

[Department of metabolism regulation. Biochemistry problems].

The publication represents main results of investigations, performed at the Department of Metabolism Regulation in 1950-1995. The problems of protein biosynthesis, fixation and the regulatory role of carboxylic acid in heterotrophic organisms were studied. The role of formic acid in metabolism and changes in metabolic processes at chronic alcoholism were investigated as well.