Discovery of Nanosota-EB1 and -EB2 as Novel Nanobody Inhibitors Against Ebola Virus Infection.

The Ebola filovirus (EBOV) poses a serious threat to global health and national security. Nanobodies, a type of single-domain antibody, have demonstrated promising therapeutic potential. We identified two anti-EBOV nanobodies, Nanosota-EB1 and Nanosota-EB2, which specifically target the EBOV glycoprotein (GP).

Digital breast tomosynthesis system concept addressing the needs in breast cancer screening and diagnosis.

Purpose: Digital breast tomosynthesis (DBT) has been introduced more than a decade ago. Studies have shown higher breast cancer detection rates and lower recall rates, and it has become an established imaging method in diagnostic settings. However, full-field digital mammography (FFDM) remains the most common imaging modality for screening in many countries, as it delivers high-resolution planar images of the breast.

Multiplex Evaluation of Biointerface-Targeting Abilities and Affinity of Synthetized Nanoparticles-A Step Towards Improved Nanoplatforms for Biomedical Applications.

To obtain versatile nanoplatforms comparable for various bio-applications, synthesis and functionalization of two inorganic nanoparticles (NPs), i.e., gold (AuNPs) and iron oxide (SPIONs), are described for different NP diameters.

Discovery of Nanosota-9 as anti-Omicron nanobody therapeutic candidate.

Omicron subvariants of SARS-CoV-2 continue to pose a significant global health threat. Nanobodies, single-domain antibodies derived from camelids, are promising therapeutic tools against pandemic viruses due to their favorable properties. In this study, we identified a novel nanobody, Nanosota-9, which demonstrates high potency against a wide range of Omicron subvariants both in vitro and in a mouse model.

Simulation of soil phosphorus dynamics and crop yield for organic and mineral fertilization treatments at two long-term field sites.

The efficacy of phosphorus (P) based fertilizers is frequently compromised by soil dynamics that render much of the applied P unavailable for crops. This study aimed to: (i) validate a new P model's prediction of plant-available P; (ii) analyze the effects of organic versus mineral fertilization on P availability and crop yield; and (iii) examine temporal changes in P pools under various fertilization regimes. Data were collected from two long-term field trials, Dikopshof and Bad Lauchstädt, in Germany, using organic (FYM), mineral (MIN), a combination of organic and mineral (MIX) fertilizers, and unfertilized treatments.