Plasmid Gene Therapy for Monogenic Disorders: Challenges and Perspectives.

Monogenic disorders are a group of human diseases caused by mutations in single genes. While some disease-altering treatments offer relief and slow the progression of certain conditions, the majority of monogenic disorders still lack effective therapies. In recent years, gene therapy has appeared as a promising approach for addressing genetic disorders.

Simulated practice in the development of clinical reasoning in nursing students: A systematic review protocol.

is a pedagogical technique that replicates real-world scenarios in a controlled environment, enabling nursing students to engage in the teaching-learning process actively. While simulated practice is a growing pedagogical strategy, several studies have examined its strengths and limitations. However, evidence of its effectiveness in developing clinical reasoning skills among nursing students still needs to be improved.

Retraction Note: Simple hemogram to support the decision-making of COVID-19 diagnosis using clusters analysis with self-organizing maps neural network.

[This retracts the article DOI: 10.1007/s00500-021-05810-5.].

Effectiveness of Combined Physical and Psychological Interventions on Anxiety and Depression Symptoms in Adult Patients With Chronic Obstructive Pulmonary Disease: a Systematic Review Protocol.

Objective: The objective of this review is to evaluate the effectiveness of combined physical and psychological interventions on anxiety and depression symptoms in adult patients with chronic obstructive pulmonary disease (COPD).

Introduction: By 2030, COPD is expected to be the third-leading cause of death and the seventh in terms of overall health impact, measured in disability-adjusted life years. As with other comorbidities, anxiety and depression disorders influence the prognosis.

Should gynecologists approach obesity? A survey analysis.

This study evaluated the prevalence of women attending gynecological consultations who wish to discuss weight issues, barriers preventing physicians from addressing obesity, and differences in perceptions between patients and physicians. A cross-sectional study was conducted from July 2021 to June 2022 at the , including 404 female patients (median age: 47.5 years) and 140 gynecologists.