Criteria for identifying and evaluating locations that could potentially host the Cosmic Explorer observatories.

Cosmic Explorer is a next-generation ground-based gravitational-wave observatory that is being designed in the 2020s and is envisioned to begin operations in the 2030s together with the Einstein Telescope in Europe. The Cosmic Explorer concept currently consists of two widely separated L-shaped observatories in the United States, one with 40 km-long arms and the other with 20 km-long arms. This order of magnitude increase in scale with respect to the LIGO-Virgo-KAGRA observatories will, together with technological improvements, deliver an order of magnitude greater astronomical reach, allowing access to gravitational waves from remnants of the first stars and opening a wide discovery aperture to the novel and unknown.

Public Health.

Background: How and why healthcare utilisation and costs vary between patients with Alzheimer's disease dementia (ADD) is not well understood but is important in ensuring that efforts to improve the diagnosis and treatment of ADD are prioritised effectively. We aimed to investigate variation in healthcare resource utilisation (HCRU) among patients with ADD in England and identify the clinical and demographic factors which characterise subpopulations with the highest HCRU.

Method: This was a retrospective cohort study using Discover, a linked electronic health record database of 2.

Drug Development.

Background: Identifying strategies to engage with potential participants is critical for efficient enrollment in Alzheimer's Disease (AD) trials. Previous studies link faster speed of first contact with successful phone interview completion for Major Depressive Disorder (MDD) participants. This has not been examined in AD participants.

Dementia Care Research and Psychosocial Factors.

Background: Loneliness, dementia, and mortality are interconnected. Thus, understanding the pathways, along with their potential interaction provides a relevant area of research to be developed.

Method: The study tested bi-directional relationships between dementia, loneliness and mortality, while examining both interactions and mediating effects in a large sample of older US adults participating in the nationally representative Health and Retirement Study.

High Detection Rate of Rotavirus Infection Among Children Admitted with Acute Gastroenteritis to Six Public Hospitals in Luanda Province After the Introduction of Rotarix Vaccine: A Cross-Sectional Study.

Rotavirus group A (RVA) is a major cause of pediatric acute gastroenteritis (AGE). Vaccination is an effective public health strategy and Angola implemented it in 2014. This hospital-based study aimed to estimate the prevalence of RVA infection and the severity of AGE in children under five years of age treated at six hospitals in Luanda Province.