Publications by authors named "M F Derbala"
Article Synopsis
- Immune checkpoint inhibitors (ICIs) have improved melanoma treatment, but finding effective drug combos with minimal side effects is essential.
- A phase 1b study tested selinexor combined with pembrolizumab on 25 patients with advanced non-uveal melanoma, revealing high rates of adverse effects but most were manageable.
- The results showed a 70% objective response rate in treatment-naïve patients, significantly better than the 7% response in those who had prior anti-PD-1 therapy, indicating promising antitumor activity.
Article Synopsis
- - This study investigates the risk of liver cancer in cirrhotic patients with indeterminate liver nodules, aiming to identify potential predictors for developing hepatocellular carcinoma (HCC).
- - Over a seven-year follow-up of 116 patients, 16% developed HCC, with significant associations found between HCC incidence and factors like smoking, nodule size over 2 cm, and specific LI-RADS scores.
- - The results highlight a concerning trend, with up to 30% of patients at risk for HCC after seven years, emphasizing the need for more intensive monitoring and clearer management strategies for these patients.
Article Synopsis
- Embryo transfer (ET) is being tested in horses to enhance genetic improvement and the study focuses on improving ET success by re-flushing and re-transferring embryos from contaminated to healthy recipient mares.
- The research involved 25 recipient mares, examining the effectiveness of embryo transfer, with 7 serving as a control group and 18 undergoing treatment to check for infections before transferring embryos.
- Results showed high rates of endometritis in control mares, leading to embryonic death, while treated mares had a better pregnancy rate, especially in embryos with well-developed capsules, highlighting the importance of monitoring and addressing uterine health.
Twin pregnancy in mares is one of the leading causes of abortions. Abortion invariably impacts both fetuses. This report describes an unusual case of a twin surviving to term following the abortion of its co-twin at 9 months in a 7-year-old Egyptian Arabian mare.
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