Astrocytic EphB3 receptors regulate D-serine-gated synaptic plasticity and memory.

The activation of classical NMDA receptors (NMDARs) requires the binding of a co-agonist in addition to glutamate. Whereas astrocytic-derived d-serine was shown to play such a role at CA3-CA1 hippocampal synapses, the exact mechanism by which neurons interact with neighboring astrocytes to regulate synaptic d-serine availability remains to be fully elucidated. Considering the close anatomical apposition of astrocytic and neuronal elements at synapses, the aforementioned process is likely to involve cells adhesion molecules.

Effects of a Self-Management Program on Adults with Stroke: A Quasi-Experimental Study.

Background: Stroke is a leading cause of death and disability, underscoring the importance of effective self-management programs to improve the quality of life for survivors.

Objectives: This study investigates the impact of the ComVida (Bridges-PT) self-management program on self-efficacy, physical function, health-related quality of life, and emotional state of stroke survivors in Portugal.

Methods: A quasi-experimental study was conducted with 28 participants from hospital and community settings.

Foot and ankle angioleiomyoma: a systematic review.

Background: Angioleiomyoma is a benign tumor arising from smooth muscle that is commonly found in the foot and ankle. This systematic review aims to synthesize the limited data from numerous case reports and case series, which often involve small sample sizes, to provide orthopaedic surgeons with a comprehensive overview of the diagnosis and management of foot and ankle angioleiomyoma.

Methods: This systematic review, performed following the PRISMA guidelines, brings updated information for the diagnosis and management of foot and ankle angioleiomyoma.

A Comparative Study of the Medial Parapatellar and Midvastus Surgical Approaches for Total Knee Arthroplasty.

 To compare the postoperative recovery outcomes of total knee arthroplasty (TKA) between the medial parapatellar (MP) and midvastus (MV) surgical approaches, focusing on quadriceps strength, knee motion range, and pain.  This retrospective study included 82 patients with degenerative knee arthropathy who underwent primary TKA. Patients were divided into two groups: one underwent MP and the other MV.

Phylogenetic Analysis of Varicella-Zoster Virus in Cerebrospinal Fluid from Individuals with Acute Central Nervous System Infection: An Exploratory Study.

Background: There is scarce information on Varicella-Zoster virus genetic variability in individuals with acute central nervous system infection in Brazil. The objective of this study was the molecular characterization of Varicella-Zoster virus isolates in cerebrospinal fluid from individuals with acute central nervous system infection.

Methods: Cerebrospinal fluid samples were collected from individuals evaluated in emergency and community healthcare services in São Paulo, Brazil.