Publications by authors named "M F C L Go"
Background: Gestational Diabetes Mellitus (GDM) affects between 2 and 10% of pregnancies in the United States, with trends of increasing prevalence and a significant amount of variability across race and ethnicity, maternal age, and insurance status. Asian and Native Hawaiian or Other Pacific Islanders (NHOPI) have been documented to have a higher prevalence and risk of developing GDM compared to non-Hispanic white populations and have been under-studied in health disparities research.
Methods: Using data from the Pregnancy Risk Assessment Monitoring System (PRAMS) 2016-2022 surveys, we conducted analyses for the overall PRAMS sample as well as within-group analyses among participants who identify as Asian and NHOPI to identify risk factors for GDM.
Article Synopsis
- The CDK4/6 inhibitor palbociclib often causes neutropenia, making it challenging to maintain the standard 3/1 dosing schedule (3 weeks on, 1 week off) for patients with hormone receptor-positive and HER2-negative metastatic breast cancer.
- A study conducted at Ogaki Municipal Hospital analyzed different dosing schedules and their impact on treatment duration, dose intensity, overall response rate, and adverse events among patients treated from January 2018 to November 2023.
- Results indicated that alternative dosing schedules (3/2 and 2/2) were associated with longer treatment durations and higher overall response rates compared to the standard 3/1 schedule, suggesting these alternatives may maintain therapeutic effectiveness.
Gremlin-2 is a novel tumor suppressor that negatively regulates ID1 in breast cancer.
Breast Cancer Res
November 2024
Background: Breast cancer is one of the most common cancers in women and is closely associated with obesity. Gremlin-2 (GREM2), an antagonist for bone morphogenetic proteins (BMPs), has been considered an inhibitor of adipogenic differentiation in adipose-derived stromal/stem cells. However, the role of GREM2 in breast cancer cells remains largely unknown, and its signaling mechanism has yet to be clarified.
View Article and Find Full Text PDFChronic exposure to particulate matter (PM) causes brain damage through intestinal imbalance. This study was estimated to confirm the regulatory activity of green tea against chronic PM exposure-induced abnormal gut-brain axis (GBA) in BALB/c mice. The green tea, as an aqueous extract of matcha (EM), ameliorated the colon length, short chain fatty acid contents, antioxidant biomarkers, myeloperoxidase (MPO) activity, and serum inflammatory cytokines.
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