Publications by authors named "M F Burattini"
Background: Hereditary amyloid transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a rare, inherited, multisystemic, progressive adult-onset disease, affecting sensorimotor nerves, and various organs. It is caused by mutations in the TTR gene, leading to misfolded monomers that aggregate, forming amyloid fibrils. Patisiran is a small, double-stranded interfering RNA encapsulated in a lipid nanoparticle, designed to enter hepatocytes and selectively target TTR mRNA to reduce both variant TTR and wild-type TTR (wt).
View Article and Find Full Text PDFIntroduction: Cancer incidence is rising in Italy, making it harder for researchers to search for innovative and comprehensive treatment strategies. The advancement of precision medicine, the hunt for molecular targets, and the development of drugs that may operate on a specific target have all become increasingly important aspects of the oncological treatment strategy in recent years. The aim of this study is to analyze the activity and performance of the Oncology and Research Center of the Marche Region (CORM) and its Molecular Tumor Board (MTB) in implementing precision medicine to improve cancer treatment.
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- Systemic inflammation raises the risk of mortality in hospitalized older patients, especially in the context of age-related diseases and infections like COVID-19.
- Inflammatory biomarkers such as the C-reactive protein to albumin ratio (CAR) and various prognostic scores (GPS, mGPS, hs-mGPS) effectively predict short-term mortality but are often underused for this purpose.
- The study involving 3,206 geriatric patients found that higher CAR and higher GPS scores significantly correlated with increased mortality risk, especially in men, indicating that these inflammatory markers can help assess in-hospital mortality risk in older adults.
Article Synopsis
- The study focuses on how electrical and mechanical functions of the heart can be affected by diseases, using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as a model for research.
- It explores innovative methods to evaluate the electrical and mechanical properties of hiPSC-CMs associated with inherited heart conditions, specifically Brugada syndrome and dilated cardiomyopathy, by organizing them into a bilayer configuration.
- The research employs advanced techniques such as high-density microelectrode arrays and various microscopy methods to measure cardiac functions and responses to stimulation, providing a comprehensive approach to understanding disease mechanisms and potential drug responses.