Publications by authors named "M F Boucher"

Three strains were cultured from the eyes of CD36-knockout mice (B6.129S1-/J) with and without keratitis housed at a biomedical research institute. Bacteria were sequenced using Illumina MiSeq technology for subsequent phylogenetic characterization and identification of virulence factor genes conferring pathogenic potential.

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Methods: The objective of this project was to determine the capability of a federated analysis approach using DataSHIELD to maintain the level of results of a classical centralized analysis in a real-world setting. This research was carried out on an anonymous synthetic longitudinal real-world oncology cohort randomly splitted in three local databases, mimicking three healthcare organizations, stored in a federated data platform integrating DataSHIELD. No individual data transfer, statistics were calculated simultaneously but in parallel within each healthcare organization and only summary statistics (aggregates) were provided back to the federated data analyst.

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Article Synopsis
  • Aripiprazole once-monthly (AOM) has shown effectiveness for treating schizophrenia, and this study explores its effects on functioning and quality of life in the second year after treatment.
  • In the ReLiAM study, patients were evaluated using various scales (GAF, SOFAS, CGI-S, QLS) over 24 months, with many maintaining their improvements from the first year.
  • Despite some mild side effects (like weight gain and insomnia), the results indicate that the benefits and tolerability of AOM continue to remain stable or improve during the second year of treatment.
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