[Features of hematopoiesis in mice protected from the lethal effect of cytosar by deoxycytidine].

Simultaneous administration to B6 female mice of deoxycytidine in doses exceeding 2--3-fold those of cytosar (20 mg/kg three times a day for 4 days) prevents lethal toxicity induced by cytosar, protects the bone marrow and spleen, hemopoietic stem cells, myeloid and erythroid cells of the bone marrow, spleen and blood. It also protects spleen and blood lymphocytes from cytosar toxic effect by does not protect thymus or bone marrow lymphocytes.

[Effect of deoxycytidine on the efficacy of cytosine arabinoside in BALB/C mice with Rauscher erythroblastic leukemia].

Intraperitoneal administration of cytosine arabinoside (araC) in a dose of 160 mg/kg/day for two days to BALB/c female mice with the advanced Rauscher erythroblastic leukemia led to a 6 fold decrease in the spleen weight and changed the spleen cytological content towards normal on the third day after therapy discontinuation. However, advanced lethal toxicity that developed at the same time resulted in the death of mice. Simultaneous administration of araC and deoxycytidine (CdR) per os in doses 3 times as high as doses of araC decreased the antitumor and toxic effects of araC.

[Selective inhibition of the primary humoral immune response in mice with a combination of deoxycytidine with Cytosar].

Cytosine arabinoside administration in lethal doses to C57BL/6j female mice immunized with red blood cells leads, under deoxycytidine protection, to reduction of serum hemagglutinin level on day 5 without toxicosis. Simultaneous injection of the metabolite and the antimetabolite proves to be optimum.

[Appearance of foci of hematopoiesis and hematopoietic stem cells in the liver of mice following a single administration of cyclophosphane].

The nidi of hemopoiesis appeared in the liver and the lymph nodes of DBA/2, C57BL/6j and F1 (C57BL/6j X CBA) strains of mice of the 6th day after a single intraperitoneal injection of cyclophosphamide in a dose of 200 mg/kg. This process was accompanied by the appearance of stem hemopoietic cells in the liver. Their maximum number was observed on the 6th and the 9th days.