Publications by authors named "M F Addo"
Background/objectives: The efficacy of monovalent BNT162b2 Omicron XBB.1.5 booster vaccination in liver transplant recipients (LTRs) has yet to be described, particularly regarding the immune response to emerging variants like JN.
View Article and Find Full Text PDFIntroduction: Vaccine platforms such as viral vectors and mRNA can accelerate vaccine development in response to newly emerging pathogens, as demonstrated during the COVID-19 pandemic. However, the differential effects of platform and antigen insert on vaccine immunogenicity remain incompletely understood. Innate immune responses induced by viral vector vaccines are suggested to have an adjuvant effect for subsequent adaptive immunity.
View Article and Find Full Text PDFArticle Synopsis
- mRNA vaccines have proven effective against COVID-19 and hold promise for other uses, as they change the activity of certain genes in the body post-vaccination.
- This study analyzed blood transcriptomes before and after mRNA vaccination to identify gene networks that are either upregulated or downregulated based on the response to the vaccine.
- The research found that specific gene networks related to immune response and processes like viral defense can be targeted for improving future vaccine designs, potentially enhancing their effectiveness.