Targeting TGF-β/VEGF/NF-κB inflammatory pathway using the Polyphenols of Echinacea purpurea (L.) Moench to enhance wound healing in a rat model.

The present study explores the metabolic profiling and molecular wound-healing mechanisms of Echinacea purpurea (L.) Moench (EP) flowers aqueous (AE) and ethanol (EE) extracts in an excision wound-healing model. Metabolic profiling of the extracts was investigated using UHPLC-ESI-TOF-MS and molecular networking.

The identification and ligation of the parotid duct during parotidectomy.

Objective: The complication rates after parotidectomy were reported to be 13-29% and many techniques were implemented to decrease these post-parotidectomy complications.

Material And Methods: Between August 2016 and June 2022, one hundred and twenty-five patients with parotid tumors had parotidectomy and ligation of the main parotid duct in the Department of Surgical Oncology, Oncology Center, Mansoura University with the observation of its effect on the postoperative outcomes.

Results: Superficial parotidectomy was performed in 87 (69.

Design, synthesis and molecular modeling of new Pyrazolyl-Benzimidazolone hybrids targeting breast Cancer.

Methyl-piperidino-pyrazole (MPP) is a pyrazole derivative acting as a lead estrogen receptor (ER) antagonist and has an anti-breast cancer effect. Since some benzimidazole derivatives were reported for their inhibitory activity against breast cancer, hybrids from these reported compounds (5a-c, 6a-c, 7a-c and 8a-c) were designed to develop anti-breast cancer agents. The synthesis involved 1,3-dipolar cycloaddition of nitrilimines on the benzimidazolone derivatives 2a-b and 3a-b which occurred with chemo- and regioselectivity depending on the dipole and was confirmed by an X-ray structure of 6b.

Asthma and Atopic Diseases in Children with Autism Spectrum Disorders.

Objective: Autism spectrum disorders (ASD) and atopic diseases are prevalent conditions affecting numerous children globally, with rising incidence rates. While both environmental and genetic factors are involved, the precise cause of this rise remains elusive. This study aims to assess the frequencies of atopic diseases in a cohort of Egyptian children with ASD.

Comparative analysis of PI and fuzzy logic controller for grid connected wind turbine under normal and fault conditions.

This research is dedicated to improving the control system of wind turbines (WT) to ensure optimal efficiency and rapid responsiveness. To achieve this, the fuzzy logic control (FLC) method is implemented to control the converter in the rotor side (RSC) of a doubly fed induction generator (DFIG) and its performance is compared with an optimized proportional integral (PI) controller. The study demonstrated an enhancement in the performance of the DFIG through the utilization of the proposed FLC, effectively overcoming limitations and deficiencies observed in the conventional controllers, this approach significantly improved the performance of the wind turbine.