Epidermal Growth Factor Receptors Unveiled: A Comprehensive Survey on Mutations, Clinical Insights of Global Inhibitors, and Emergence of Heterocyclic Derivatives as EGFR Inhibitors.

Mutations that overexpress the epidermal growth factor receptor (EGFR) are linked to cancers like breast (15-20%), head and neck (10-15%), colorectal (5-8%), and non-small cell lung cancer (10-50%), especially in East Asian populations. EGFR activation stimulates "RAS/RAF/MEK/ERK, PI3K/Akt, and MAPK" pathways, which enhance cell division, survival, angiogenesis, and tumor growth while inhibiting apoptosis and metastasis. Secondary mutations (e.

Correction: Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents.

[This corrects the article DOI: 10.1371/journal.pone.

Evaluation of high temperature impacts and nanotechnology as a shield against temperature stress on tomatoes - A review.

Rising temperature due to changing climate significantly impacts the production of tomato. The morpho-physiological functions of tomato such as gas exchange, growth and development, flowering, fruit setting, quality, fruit size, weight that can influence the yield and production is drastically affected by higher temperatures. Among the growth stages of tomato, flowering and fruit setting stage is highly vulnerable to high temperature resulting in reduced flower numbers, increased flower abortion, stigma exertion, abnormal ovule, reduced pollen germination, pollen numbers, pollen tube development, pollen viability and increased male sterility.

Comparative study in treatment of acne scars fractional carbon dioxide laser versus micro needling fractional radio frequency - A retrospective study.

Objectives: Efficacy of fractional carbon dioxide laser and microfractional radiofrequency in treatment of acne scars is well substantiated. The objective of this study was to compare the efficacy and safety of carbon dioxide laser versus microfractional radiofrequency in treatment of acne scars in skin type 3,4.

Material And Methods: Thirty-two patients of skin types 3-4 with grade 3 and 4 atrophic acne scars, of which 16 were treated with fractional carbon dioxide (CO) laser and 16 were treated with microfractional radiofrequency were retrospectively analyzed.