Learning Experiences in an Intensive Vaccination Training Course in Japan: A Qualitative Study.

Introduction: Medical students rarely have opportunities to perform common clinical procedures, and this is especially true in Japan. An intensive vaccination training course was developed to resolve this issue. Medical students experienced (almost) their first experience with needles in a live person with the help of their colleagues and supervisors and seemed to learn various things during the course.

Nomogram predicting the outcome of salvage radiation therapy for prostate-specific antigen failure following radical prostatectomy: an exploratory analysis of a randomized, multicenter, open-label, phase 3 trial (JCOG0401).

Background: We have demonstrated that patients with prostate-specific antigen failure following radical prostatectomy benefit from salvage radiation therapy prior to salvage hormone therapy in a multicenter, randomized, open-label, phase 3 trial (JCOG0401). This study aimed to develop a nomogram to predict the efficacy of salvage radiation therapy in patients with prostate-specific antigen failure following radical prostatectomy.

Methods: This exploratory study focused on the salvage radiation therapy arm of the JCOG0401 trial and explored clinical factors that were significantly associated with the time to treatment failure of salvage radiation therapy using univariable and multivariable analyses.

Primary management of prostate cancer by universal health coverage effective coverage index.

Purpose: Prostate cancer is under-researched in many Asian countries because the paucity of comprehensive cancer registries has prevented large studies from comparing primary prostate cancer therapies. We aimed to provide further insights into recent trends in primary prostate cancer management across multiple Asian countries and regions according to universal health coverage.

Methods: This is part of the Asian Prostate Cancer (A-CaP), a prospective and multicenter study conducted in 12 Asian countries.

Genomic characterization of metastatic patterns in prostate cancer using circulating tumor DNA data from the SCRUM-Japan MONSTAR SCREEN project.

Purpose: Genomic characterization of the predisposition of tumors to metastasize to specific sites has been performed in a few studies using mainly tissue-derived genomes. This nationwide prospective observational study investigated the association between genomic characteristics using circulating tumor DNA (ctDNA), and the synchronous and metachronous metastasis of tumors to specific target organs in advanced prostate cancer.

Methods: Patients with advanced prostate cancer undergoing systemic treatment were included.

Multiomics analysis unveils the cellular ecosystem with clinical relevance in aldosterone-producing adenomas with mutations.

Aldosterone-producing adenomas (APA), a major endocrine tumor and leading subtype of primary aldosteronism, cause secondary hypertension with high cardiometabolic risks. Despite potentially producing multiple steroid hormones, detailed cellular mechanisms in APA remain insufficiently studied. Our multiomics analysis focusing on APA with mutations, which represent the most common genetic form, revealed marked cellular heterogeneity.