Publications by authors named "M Esther Martinez-Pardo"
Article Synopsis
- Phenylketonuria (PKU) is a hereditary disorder that affects protein metabolism, first identified in newborn screenings, leading to earlier diagnosis and treatment for affected individuals.
- A case study focused on a 28-year-old woman with PKU highlights the complexities of her pregnancy, involving both her and her partner's PKU diagnoses, which have implications for the fetus.
- The findings stress the importance of careful pregnancy management and monitoring in women with PKU, suggesting the potential benefit of genetic studies in understanding fertility related to the condition.
Radiosterilized pig skin (RPS) has been used as a dressing for burns since the 1980s. Its similarity to human skin in terms of the extracellular matrix (ECM) allows the attachment of mesenchymal stem cells, making it ideal as a scaffold to create cellularized constructs. The use of silver nanoparticles (AgNPs) has been proven to be an appropriate alternative to the use of antibiotics and a potential solution against multidrug-resistant bacteria.
View Article and Find Full Text PDFExtensive burns represent a significant challenge in biomedicine due to the multiple systemic and localized complications resulting from the major skin barrier loss. The functionalization of xenografts with nanostructured antibacterial agents proposes a fast and accessible application to restore barrier function and prevent localized bacterial contamination. Based on this, the objective of this work was to functionalize a xenograft by electrospray deposition with silver nanoparticles (AgNPs) and to evaluate its antibiofilm and cytotoxic effects on human fibroblasts.
View Article and Find Full Text PDFArticle Synopsis
- Propionic acidaemia (PA) is a metabolic disorder caused by a lack of the enzyme propionyl-CoA carboxylase, leading to acute decompensation and potential long-term complications from mitochondrial dysfunction.
- A study involving seven PA patients aged 2.5 to 20 years examined the effects of Coenzyme Q10 (CoQ10) supplementation in the form of ubiquinol, showing that it corrected initially low plasma CoQ10 levels and was well tolerated.
- Supplementation resulted in significant increases in urinary citrate and the citrate/methylcitrate ratio, indicating potential improvements in mitochondrial function and anaplerosis, warranting further investigation for preventing chronic complications in PA.