Publications by authors named "M Esparza"
Case: Three cases of pediatric patients with knee injuries from cactus thorns are included. These cases are variable in presentation ranging from acute inflammatory responses to permanent limb deformity secondary to growth arrest. Definitive treatment also varied widely from nonoperative conservative management to multiple arthroscopic and open surgeries.
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- Non-pharmacological interventions could improve quality of life for individuals with primary progressive aphasia (PPA) and their caregivers but need more efficacy trials.
- The Communication Bridge-2 (CB2) trial is the first international, video chat-based randomized controlled trial focusing on speech-language interventions for PPA.
- The trial successfully recruited and randomized 95 participant dyads across four countries, demonstrating that global recruitment for non-drug trials in this field is feasible and may serve as a model for future research in Alzheimer's and related dementias.
Tau has a wide variety of essential functions in the brain, but this protein also plays a determining role in the development of Alzheimer's disease (AD) and other neurodegenerative diseases called tauopathies. This is due to its abnormal aggregation and the subsequent formation of neurofibrillary tangles. Tau hyperphosphorylation appears to be a critical step in its transformation into an aggregated protein.
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- Copy number variants (CNVs) are linked to psychiatric disorders and brain structure changes, but the specific gene effects within the CNV regions, like 22q11.2, are still unclear.
- This study focuses on Tbx1, a gene in the 22q11.2 region, exploring how it influences brain volume and behaviors through a detailed analysis of Tbx1 heterozygous mice using magnetic resonance imaging.
- Results showed decreased volumes in key brain areas associated with social behavior and learning, while some auditory regions were larger, highlighting the nuanced impacts of Tbx1 on brain structure and function.
Article Synopsis
- Influenza A viruses contain eight genomic RNAs that are transcribed in the host cell nucleus, with two undergoing alternative splicing to produce M1 and M2 mRNAs.
- The NS1-BP protein helps facilitate the splicing of M1 to M2 mRNA by competing with the viral NS1 protein, which normally inhibits mRNA export.
- The research suggests a mechanism where spliced M mRNAs are exported from the nucleus despite NS1's inhibitory effects, crucial for the production of viral proteins needed for replication and virus release.