Metabolism of doxorubicin in long-term bone marrow cultures and SR-4987 stromal established cell line.

The metabolism of doxorubicin was studied in murine long-term bone marrow cultures (LTBMC) and in SR-4987 established stromal cells in comparison with primary cultures of murine and rat hepatocytes. The toxicity of metabolites was verified by testing their effects on the clonogenicity of granulo-macrophage progenitors. Metabolic activity was compared in subcellular fractions of SR-4987 cells and murine hepatocytes.